2?-O methylation of RNA cap in SARS-CoV-2 captured by serial crystallography
نویسندگان
چکیده
Significance The 2?-O methyl group in Cap-1 is essential to protect viral RNA from host interferon-induced response. We determined crystal structures of SARS-CoV-2 Nsp10/16 heterodimer complex with substrates (Cap-0 analog and S-adenosyl methionine) products (Cap-1 S-adenosyl-L-homocysteine) at room temperature using synchrotron serial crystallography. Analysis these will aid structure-based drug design against 2?-O-methyltransferase SARS-CoV-2.
منابع مشابه
SARS-CoV-2 infection: its psychiatric manifestations
Background: The clinical presentation of SARS-CoV-2 infection was initially dominated by respiratory symptoms. However the clinical spectrum is wide and neuropsychiatric syndromes are also a source of medical concern. Our aims are to present an atypical clinical presentation of SARS-CoV-2 infection characterized by auditory hallucinations and unusual behavior and to emphasize the diversity of ...
متن کاملمروری به بررسی ایمونولوژیکی SARS-Cov-2
زمینه و هدف بیماری کووید-19 یک بیماری عفونی بهشدت مسری میباشد که توسط یک کروناویروس جدید ایجاد میشود که میتواند از انسان به انسان از طریق تماس نزدیک منتقل شود. هدف از مطالعه حاضر بررسی اطلاعات جدید در زمینه ایمونولوژی کووید-19 میباشد. مواد و روشها در مطالعه مروری حاضر، از موتورهای جستجوی Google و Google Scholar و مقالات نمایه شده در پایگاههای علمی معتبر بینالمللی از جمله Pub Med، MedLi...
متن کاملSARS-CoV-2: A Review Of Present & Future Perspectives
As the dawn of this new decade has begun, we have faced our arch-nemesis right at the start in the form of Coronavirus also known as COVID-19. Since its origin from Wuhan, China, it has been declared a pandemic and has effected several countries worldwide. This review article summarizes all the research, techniques, strategies, and treatment methodologies that are taking place internationally i...
متن کاملGastrointestinal Manifestations in Patients Infected with SARS-CoV-2
Coronavirus disease 2019, caused by severe acute respiratory syndrome coronavirus 2, has recently become the number one problem affecting global health. Coronavirus disease 2019 is principally recognized by its respiratory manifestations; however, recent studies have shown an increasing number of patients with gastrointestinal complaints like diarrhea, nausea, vomiting, and abdominal discomfort...
متن کاملAssessment of protection against SARS-CoV-2 infection by measuring antibody titer, yes or no!
Dear Editor The current epidemic of the novel Coronavirus disease 2019 (COVID-19) risen from Wuhan, China, turned into a worldwide concern because of its incubation period (2-14 days) and its high transmission rate. The first cases of the infection were reported in December 2019 in Wuhan with symptoms like pneumonia for an unknown reason. Very soon it was known as a novel kind of Coronavirus o...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences of the United States of America
سال: 2021
ISSN: ['1091-6490', '0027-8424']
DOI: https://doi.org/10.1073/pnas.2100170118